A research discussion took place in the College of Medicine for a student of the Iraqi Council for Medical Specialization in pathology / pathological histology, which is part of the requirements for obtaining a board certificate (PhD) in pathology for a student of the board, Doha Talib Karim
Titled:
((Histological and immunohistochemical expression of CATENIN in urothelial carcinoma according to histopathological criteria in a group of Iraqi patients))
This study revealed that urothelial cancer is an important cause of cancer-related morbidity and mortality and constitutes nearly 90% of all primary bladder cancers.
The depth of invasion and the degree of histological differentiation of the tumor are the most important predictive criteria for the biological behavior of urothelial carcinomas. Β-Catenin is part of the cadherin protein complex; It also functions as an intracellular signal transducer in the WNT signaling pathway that has been identified in many different tissues such as colorectal epithelium that regulates angiogenesis, proliferation and invasion of malignancy.
It was also discovered that B-catenin/ Wnt pathways are responsible for regulating homeostasis in the urothelial epithelium and tumorigenesis of Wnt/ β-catenin, and mutation and overexpression of B-catenin is associated with worse disease behavior.
The aim of this study was to evaluate the histochemical and immunohistochemical expression of B-catenin in urothelial carcinoma and its association with histopathological parameters including tumor differentiation score, muscle invasion as well as B-catenin 2. B-catenin can be used as a predictive indicator for urothelial carcinoma of the urinary bladder. .
The researcher concluded in her thesis that the expression of B-catenin increases significantly with the increase of differentiation degree and stage of urothelial carcinoma as a predictive indicator for B-catenin cancer.
Urinary epithelium may be used in the urinary bladder
The committee supervising the discussion has recommended granting it the degree of excellence for the effort of the researcher, Duha Talib Karim
