A thesis at Karbala University achieves the transformation of a highly toxic treatment into a treatment directed at cancer cells

A dissertation at the Faculty of Medicine, University of Karbala discussed the discovery of a modern porous hybrid material consisting of metal ions and organic bonds, a promising biomedical material due to its unusual properties, including large pore size, high surface area and drug loading. Alpha 1 (Orosomucoid) in breast cancer patients and also examining the feasibility of using nanoparticle drug delivery systems to deliver therapeutic materials to cancer cells. Ismail) The study, which carries four very important chapters, came first in linking the types of modern treatments, while the second was in the method of work and included 40 patients with breast cancer, and the third was in the results and its relationship to protein and the type of treatment, and the fourth came in the conclusions and gives the protein to the therapist about the patient’s response to chemotherapy, where The thesis aims to manufacture the nanocomposite and study the properties, especially the toxicity of the compound towards healthy cells and increase its targeting of cancer cells, as discussed by Al-Rass Anticancer drug (GEM) loading machine (GEM) Gemcitabine hydrochloride and Amygdalin (Amy) in the framework of a ZIF-8-8 zeolite imidazolate complex using bovine albumin (bsa) as the central compound and pH-sensitive ZIF-8 as a coating then BSA-GEM@ZIF-coated BSA—Gem-amy @zif-8 with polydopamine, successively chelated with Au3+ and conjugated with gallic acid (AG), finally resulted in the production of multifunctional ZIF nanocarriers.