The master’s thesis in the Department of Medical Microbiology, College of Medicine, University of Karbala discussed the effect of the bacterial respiratory microbiome on the level of serum IL-37 and IL-38. The thesis submitted by the researcher (Dhu al-Nurain Hassan Hadi Alwan) included the title “The effect of the bacterial respiratory microbiome on the level of serum IL-37 and IL-38 with a correlation to the severity of recurrent wheezing”
The discussion committee consisted of:
Prof. Dr. Abeer Zaher Naji, Chairman
Assistant Assistant Dr. Israa Saeed Abbas, Member
Assistant Assistant Dr. Zainab Jaber Hadi, Member
Prof. Dr. Susan Muhammad Jabbar, Supervisor
Assistant Assistant M.D. Mai Mohammed Ali Mohammed Musharraf
The study aimed to evaluate the relationship between the bacterial respiratory microbiome and IL-37, IL-38 with the severity, type and control of asthma through the following objectives:
Identify the type of bacterial microbiome in the respiratory tract of children with asthma and healthy children.
Detect immune markers (IgE total, IL-37, IL-38) in serum by ELISA test in both patients and healthy individuals.
Relate the growth of some microbes and IL-38, IL-37 in serum to laboratory blood tests such as complete blood count (eosinophils, neutrophils and lymphocytes)
Relate the growth of some microbes and IL-37, IL-38 in serum to the severity, type and control of asthma.
Therefore, identifying the growth of microbiome associated with more severe or uncontrolled asthma or allergic asthma is essential for a better understanding of the pathophysiology of childhood asthma in Iraq. In addition to identifying the role of IL-37 and IL-38 in the pathogenesis of asthma.
The study also found that there was a significant increase in the levels of both IL37 and IL38 in recurrent wheezing, which may act as inflammatory markers or precursors of the disease process. Both IL37 and IL38 can be considered good diagnostic biomarkers for recurrent wheezing.
