A master’s thesis in the Microbiology Branch at the College of Medicine, University of Karbala, discussed the role of assessing immune-related genes in the development of systemic lupus erythematosus in Iraqi patients. The letter submitted to the researcher (Fatima Abdel Hussein Kazem Abdel Hassan) included the title:
Evaluation of autoimmunity-associated genes (ITGAM) (TNFAIP3) and IFNα cytokines (TLR7) for the development of systemic lupus erythematosus in Iraqi patients.
The discussion committee consisted of:
a. Dr.. Alaa Saad Hanfoush, Chairman
a. Dr. Hamed Abdel Hussein Al-Habali, member
a. Dr. Salem Hussein Hassan, member
a. Dr.. Riyad Dahoud Al-Zubaidi, supervisor
Professor Dr. Sattar Jabbar, supervisor
The study aimed to evaluate the genetic expression of some genes (ITGAM, TNFAIP3, and IFN α cytokines) (TLR7) associated with systemic lupus erythematosus to follow the disease among patients in some governorates of Iraq.
SLE is a chronic autoimmune disease that occurs when the immune system attacks the body’s tissues and organs. Despite the difficulties associated with the disease, the total number of lupus erythematosus cases is estimated at 134 cases per 100,000 people worldwide.
The study also found that socio-demographic factors such as gender, marital status, and family history affect susceptibility to lupus, as the values of antibodies to (ANA) and (dsDNA) were significantly higher in the serum of lupus patients compared to healthy patients. . . . Values, where ANA (for SLE patients, 8.79 ± 4.57 IU/mL, versus IU/m < 1.2 normal range for SLE) and dsDNA (36.55 ± 12.23 IU/mL for SLE patients, versus IU/M < 20 normal range ), (in addition to low levels of complement C3 proteins). and C4 in SLE patients compared with normal range values (C3, 1.09 ± 0.37 g/L SLE vs. 1.85-0.8 g/L normal range) and C4, 0.30 ± 0.11 g/L for SLE patients vs. 0.4-0.1 g/L for SLE. . . . . natural
