The Iraqi Board of Pathology at the College of Medicine, University of Karbala, discussed a thesis on the role of immunohistochemical expression in breast cancer patients. The study, presented by researcher Mariam Mahdi Salman, titled “The Association of Immunohistochemical Expression of Sox10 with Triple-Negative Breast Cancer,” aimed to evaluate the immunohistochemical expression of SOX10 in triple-negative breast cancer and its correlation with tumor grade and other pathological clinical characteristics.
The study found that the immunohistochemical expression of SOX10 was positive in 43% of the cases, which equals thirteen out of thirty cases, while 57% were negative, equating to seventeen cases. This positivity was significantly associated with the degree of differentiation (p-value = 0.012) and the clinical stage of the disease (p-value = 0.038). Statistical significance was also found in association with lymph node involvement and distant metastases (p-values = 0.039 and 0.037, respectively).
Among the thirteen positive cases, nine were found to be of the third degree of differentiation, and the remaining four cases were of the second degree. There were no cases of the first degree of differentiation.
