The master’s thesis of the Biochemistry (Medical) Branch at the College of Medicine, University of Karbala, by a student, Zainab Ali Hadi, discussed her thesis, tagged in sickle cell anemia (SCD), which is the most common genetic disorder of hemoglobin (HB), which affects nearly a million people worldwide.
Oxidative stress plays a major role in the pathophysiology of hemolysis, vascular occlusion, and subsequent organ damage in sickle cell patients. Hematopoiesis and accelerated hemolysis, thus affecting many body systems. Within the gastrointestinal tract, the biliary tract is most commonly involved in sickle cell disease. Symptoms range from hyperbilirubinemia to liver failure, with a range of severe clinical symptoms often referred to as sickle cell hepatitis.
The aim of the study was to manufacture a new nanocomposite consisting of ferromagnetic iron oxide particles coated with Prussian blue dye and to investigate its ability to remove precipitated bilirubin.
Also, these cases and controls were studied for a period of 6 months (May) and (October) 2022, in Karbala Teaching Hospital for Pediatrics and advanced postgraduate laboratories in the Department of Chemistry and Chemistry.
Biochemistry at the College of Medicine at Karbala University.
The results of the study showed a decrease in the levels of serum GPX and GSH with a statistically significant difference (P < 0.001) and an increase in the level of MDA with a significant difference (P < 0.05) in patients compared to the healthy group. While there are no statistically significant differences in the levels of CAT function tests in patients compared to the healthy group.
