Professor Haider Abdel-Amir Najm, the teaching assistant in the Pharmaceutical Branch, College of Medicine, University of Karbala, participated in the discussion of master’s student Russell Kazem Bakheet and the title of her thesis (the effect of non-steroidal anti-inflammatory drugs on cellular proliferation and cytokine production in colorectal cancer cell line), under the supervision of Assistant Professor Dr. Majid Kazem Abbas, and the discussion took place at the Faculty of Medicine, Pharmacology and Toxicology Branch.
In defending her message, the researcher stated that colorectal cancer (CRC) is one of the leading tumors in the world and is considered one of the biggest killers, along with lung, prostate and breast cancer. Colorectal cancer is also known as colorectal adenocarcinoma. There is a significant risk of CRC in individuals whose adenomas have not been removed, and polypectomy reduces the risk of CRC.
Colorectal cancer (CRC) shows differences in incidence, pathogenesis, molecular pathways, and outcome depending on the location of the tumor. Treatment may include surgery, radiotherapy, and chemotherapy which are often associated with many side effects, toxicity and costly, significantly affecting patients’ quality of life. Non-steroidal anti-inflammatory drugs (NSAIDs) are known COX inhibitors, and they are certainly a popular anticancer candidate in cancer treatment and prevention.
The use of NSAIDs in colorectal cancer because they are excreted and can be used as a preventative for CRC and can be used in combination with other cancer drugs.
The purpose of this study is to investigate the cytotoxic effect of non-steroidal anti-inflammatory drugs (aspirin, sulindac, and celecoxib) on the SW480 colorectal cancer cell line.
The immunomodulatory effects of NSAIDs were revealed by measuring the production of cytokines in the supernatants of colorectal cancer cells in response to NSAIDs.
The results demonstrated anti-proliferative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the colorectal cancer cell line when each drug was used alone or in combination with immune-modulating effects on cytokine production.
