A master’s thesis at the University of Karbala, College of Medicine, Department of Medical Microbiology, by student Amer Muhsin Ibrahim, entitled “Evaluation of Neutral Gelatinase-Related Myeloperoxidase, Lipocalin, and Toll-like Receptor as Indicators of Myocardial Infarction in Type 2 Diabetic Patients,” was discussed. The study aimed to:
Evaluate the relationship between type 2 diabetes mellitus (T2DM) and ischemic heart disease (IHD), and investigate the effect of certain inflammatory and cardiac biomarkers, such as hs-cTn, HbA1c, TLR4, NGAL, and MPO, on the risk of developing IHD in type 2 diabetic patients.
It also sought to determine the role of chronic inflammation and reduced blood flow in increasing the risk of heart disease among diabetic patients.
The results showed a significant increase in the levels of cardiac and inflammatory biomarkers in diabetic patients with ischemic heart disease compared to those without. The study recorded a significant increase in HbA1c, hs-cTn, TLR4, NGAL, and MPO in diabetic patients with ischemic heart disease.
However, high-density lipoprotein (HDL) cholesterol levels did not show any significant difference between the groups.
The study also recommended:
The study emphasizes the necessity of comprehensive diabetes management through controlling HbA1c, lipid levels, and inflammation to reduce the risk of heart disease. The results support the importance of using biomarkers (TLR4, MPO, NGAL, hs-cTn) as diagnostic and predictive tools to estimate the risk of ischemic heart disease in diabetic patients.
The study recommends the necessity of assessing multiple risk factors (glycemia, lipids, inflammation, and blood pressure) within the treatment and follow-up programs for diabetic patients to prevent cardiac complications.
The discussion committee consisted of:
Prof. Dr. Ahmed Abbas Hassan / Chairman
Prof. Dr. Haider Faisal Ghazi / Member
Assistant Professor Dr. Masar Riyadh Al-Mousawi / Member
Prof. Dr. Alaa Saad Hanfoush / Member and Supervisor
Prof. Dr. Dhumia Makki Hamza / Member and Supervisor.
